Burden of Clostridium difficile Infection (CDI) Across Whole Healthcare Economies and European Borders; COMBACTE-CDI Results

Does empirical Clostridium difficile infection (CDI) therapy result in false-negative CDI diagnostic test results?

BACKGROUND Patients with suspected Clostridium difficile infection (CDI) often receive empirical therapy prior to collection of stool specimens for diagnostic testing. The likelihood that such empirical therapy might result in false-negative CDI test results is unknown. METHODS We conducted a prospective study of CDI patients to determine the time to conversion of CDI test results, including ...

New advances in the treatment of Clostridium difficile infection (CDI)

Clostridium difficile infections (CDI) have increased in frequency throughout the world. In addition to an increase in frequency, recent CDI epidemics have been linked to a hypervirulent C. difficile strain resulting in greater severity of disease. Although most mild to moderate cases of CDI continue to respond to metronidazole or vancomycin, refractory and recurrent cases of CDI may require al...

The burden of clostridium difficile infection: estimates of the incidence of CDI from U.S. Administrative databases

BACKGROUND Many administrative data sources are available to study the epidemiology of infectious diseases, including Clostridium difficile infection (CDI), but few publications have compared CDI event rates across databases using similar methodology. We used comparable methods with multiple administrative databases to compare the incidence of CDI in older and younger persons in the United Stat...

The Burden of Clostridium Difficile (CDI) Infection in Hospitals, in Denmark, Finland, Norway And Sweden.

The recurring nature of CDI is a difficult-to-treat problem which has a substantial impact on hospitalisations, extending length of stay, hospital costs associated with isolation rooms and decontamination, and patients’ quality of life [5]. Cases of mild-moderate CDI are usually treated in the outpatient setting while patients with severe CDI are typically hospitalized. However, even mild-moder...

Use of Electronic Data to Identify Risk Factors Associated with Clostridium difficile Infection (CDI) and to Develop CDI Risk Scores